Selena (Kate Beckinsale) is a warrior and more importantly, she's a vampire who hunts werewolves. The Lycans (which is what werewolves are really called) and the Vampires have been involved in bloody feud that has lasted about 600 years. No one knows exactly when it started or why, only that that's the way things are.
And while the feud has always been a constant, some things have changed. Like the fact that the moon is no longer required as Lycan can will themselves to change. They've also managed to create weapons that can kill vampires. This is troubling to the warriors because it reminds of them of the time when The great Lycan, Lucian, the one who almost destroyed them all and won the war.
But this is impossible because the great Lucian was killed by the current leader of the Vampires, Kraven (Shane Brolly) and the werewolves were hunted to the brink of extinction. But something is going on that has the werewolves acting bold. They've also become fixated on anyone with the last name of Corvin, including Michael Corvin a young American doctor now working abroad.
Selena finds herself attracted to him ,but he is human and the Lycan's want him, to further complicate matters he ends up being bitten by a Lycan and will turn into one. She is conflicted by her attraction to him; 600 years of being a sworn enemy of the Lycan's; and needing to find out why they want him.
She's digging for the truth, but it is a truth she doesn't want to know.
Rated R; running time of 120 minutes 